Mechanistic Model of Radiation-Induced Bystander Effects to Cells using Structured Population Approach

Authors

  • Fuaada Mohd Siam Department of Mathematical Sciences, Faculty of Science, Universiti Teknologi Malaysia, 81310, UTM Johor Bahru, Johor, Malaysia
  • Muhamad Hanis Nasir Department of Mathematical Sciences, Faculty of Science, Universiti Teknologi Malaysia, 81310, UTM Johor Bahru, Johor, Malaysia

DOI:

https://doi.org/10.11113/matematika.v34.n3.1147

Abstract

In irradiation process, instead of traverse on the targeted cells, there is side effect happens to non-targeted cells. The targeted cells that had been irradiated with ionizing radiation emits damaging signal molecules to the surrounding and then, damage the bystander cells. The type of damage considered in this work is the number of double-strand breaks (DSBs) of deoxyribonucleic acid (DNA) in cell’s nucleus. By using mathematical approach, a mechanistic model that can describe this phenomenon is developed based on a structured population approach. Then, the accuracy of the model is validated by its ability to match the experimental data. The Particle Swarm (PS) optimization is employed for the data fitting procedure. PS optimization searches the parameter value that minimize the errors between the model simulation data and experimental data. It is obtained that the mathematical modelling proposed in this paper is strongly in line with the experimental data.

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Published

2018-12-31

How to Cite

Mohd Siam, F., & Nasir, M. H. (2018). Mechanistic Model of Radiation-Induced Bystander Effects to Cells using Structured Population Approach. MATEMATIKA: Malaysian Journal of Industrial and Applied Mathematics, 34(3), 149–165. https://doi.org/10.11113/matematika.v34.n3.1147